The jet formation caused by the collapse of a liner is dependent mainly upon the explosive characteristics loaded in shaped charge warhead. In this study, the purpose was to compare the influence of Octol and PBXN-110 fillers on performance of a specific shaped charge warhead. This material loaded into the aluminum-cased shaped charge having a 35° copper  liner and 510 cm³ in capacity. Results obtained by numerical simulation (LS-Dyna) indicated that the most effective stand-off is 50 cm. Based on simulation data, octol has a higher penetration compared to PBXN-110 for the same stand-off. Results from the experimental tests also showed that the warheads loaded with octol and PBXN-110 have penetration about 444 mm and 324 mm respectively. PBXN-110 exhibit a weak penetration effect due to its lower density and detonation velocity compared to Octol.